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KMID : 1094720090140020232
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Biotechnology and Bioprocess Engineering
2009 Volume.14 No. 2 p.232 ~ p.237
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Comparative Evaluation of Antioxidant, Nitrite Scavenging, and Antitumor Effects of Antrodia camphorata Extract
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Cha Wol-Suk
Ding Ji-Lu
Choi Du-Bok
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Abstract
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The effects of decoctions prepared from Antrodia camphorata on antioxidant, nitrite scavenging, and antitumor activities were investigated. Glutathione (GSH) production was 18.2 꺷M/g of rat liver under the influence of a methanol extract, a result similar to with the effect of silymarin administration. GSH peroxidase activity was about 2.0-fold higher than with silymarin administration. Superoxide dismutase activity was 18.9 U/mg protein, about 2.5-fold higher than the control group. The hot water extract (1000 꺷g/mL) showed the highest nitrite scavenging activity at 98.1%, similar to those observed with BHA and vitamin E. Among a variety of human cancer cell lines, when the concentration of hot water extract was increased from 31 to 500 꺷g/mL, the viability of Hep3B cell was decreased from 100 to 60.7%. On the other hand, in the case of methanol extract, it was decreased from 98.4 to 10.0%. These results supported the conclusion that the antioxidant, nitrite scavenging, and antitumor activities of this A. camphorata methanol extract indicate a potential source for the development of various health supplements and pharmaceutical and nutraceutical applications.
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KEYWORD
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Antrodia camphorata, antioxidant, nitrite scavenging, antitumor activities
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